Table 1.
Patients’ demographics.
| Chemotherapy group | |
|---|---|
| Participants (n) | 708 |
| Age (years)# | 70.4 ± 6.9 |
| Sex (male/female) | 645/63 |
| Smoking history (presence/absence/unknown) | 684/20/4 |
| Smoking index (pack-years)# | N = 677, 55.3 ± 30 |
| Emphysema (presence/absence/unknown) | 326/381/1 |
| Performance status | |
| 0/1/2/3/4 | 226/378/84/16/4 |
| Interstitial pneumonia | |
| Clinical diagnosis of IIP (IPF/non-IPF/unknown) | 406/294/8 |
| HRCT pattern | |
| UIP pattern | 275 |
| Possible UIP pattern | 243 |
| Inconsistent with the UIP pattern | 190 |
| History of acute exacerbation (presence/absence/unknown) | 11/689/8 |
| Desaturation on exertion (presence/absence/unknown) | 80/418/210 |
| %FVC (%)# | n = 441, 88.6 ± 19.14 |
| %DLco (%)# | n = 238, 64 ± 22.56 |
| KL-6 (U/mL)# | n = 564, 922.8 ± 985.25 |
| SP-D (ng/mL)# | n = 406, 135.6 ± 102.9 |
| Treatment | |
| None | 678 |
| Prednisolone | 15 |
| Prednisolone + immunosuppressants | 5 |
| Pirfenidone | 7 |
| NAC | 1 |
| Pirfenidone + NAC | 1 |
| Pirfenidone + prednisolone | 1 |
| Lung cancer | |
| Histopathologic type | |
| Small cell carcinoma | 216 |
| Non-small cell carcinoma | 492 |
| Adenocarcinoma | 258 |
| Squamous cell carcinoma | 173 |
| LCNEC | 17 |
| LCC | 9 |
| Others | 35 |
| EGFR mutation status | |
| Negative | 274 |
| Positive | 13 |
| L858R/deletion 21 | 9/4 |
| Not evaluated | 421 |
| ALK re-arrangement | |
| Negative | 124 |
| Positive | 2 |
| Not evaluated | 582 |
ALK anaplastic lymphoma kinase, BSC best supportive care, EGFR epidermal growth factor receptor, %DLco percentage of predicted diffusing capacity of the lung for monoxide, %FVC percentage of predicted forced vital capacity, HRCT high-resolution computed tomography, IIP idiopathic interstitial pneumonia, IPF idiopathic pulmonary fibrosis, KL-6 Krebs von den Lungen-6, LCC large cell carcinoma, LCNEC large cell neuroendocrine carcinoma, NAC inhaled N-acetylcysteine, PS eastern cooperative oncology group performance status, SP-D surfactant protein-D, UIP usual interstitial pneumonia.
#Mean ± standard deviation.