Table 3.
Prognosis factor of cirrhosis-related IgAN
| Characteristics | Progressor n = 8 | Nonprogressor n = 20 | P-value |
|---|---|---|---|
| Baseline features | |||
| Age (yr) mean±SD | 67 ± 9 | 59 ± 10 | 0.03 |
| Female (%) | 0 (0%) | 5 (25%) | 0.28 |
| History of decompensated cirrhosis | 4 (50%) | 10 (50%) | 1 |
| Serum creatinine (mg/dl) mean±SD | 5.1 ± 1.7 | 2.7 ± 2 | 0.008 |
| Acute kidney injury, n (%) | 7 (88%) | 11 (55%) | 0.19 |
| Alternative causes of AKI | 5 (63%) | 9(45%) | 0.68 |
| Proteinuria (g/g) median (IQR) | 3.5 (2–5.3) | 2.8 (1.2–4.3) | 0.4 |
| Histological features | |||
| MPGN pattern | 3 (38%) | 1 (5%) | 0.058 |
| M1 | 5 (63%) | 9 (45%) | 0.68 |
| E1 | 3 (38%) | 6 (30%) | 1 |
| S1 | 4 (50%) | 7 (35%) | 0.67 |
| T 1 | 4 (50%) | 5 (25%) | 0.37 |
| C 1 | 1 (13%) | 3 (15%) | 1 |
| Vascular lesion | |||
| Ischemic glomeruli, n (%) | 5 (63%) | 7 (35%) | 0.23 |
| Arteriolar hyalinosis, n (%) | 4 (50%) | 7 (35%) | 0.67 |
| Fibro-intimal thickening, n (%) | 6/7 (86%) | 14 (70%) | 0.63 |
| Thrombotic microangiopathy, n (%) | 1 (13%) | 1 (5%) | 0.50 |
| Presence of interstitial inflammation | 5 (63%) | 12 (60%) | 1 |
| Acute tubular necrosis | 7 (88%) | 13 (65%) | 0.37 |
| Management | |||
| Steroids | 2 (25%) | 2 (10%) | 0.55 |
| ACEi or ARB without steroids | 4 (50%) | 11 (55%) | 1 |
ACEi, angiotensin- converting enzyme inhibitor; AKI, acute kidney injury; ARB, angiotensin receptor blocker; CKD, chronic kidney disease; IgAN, IgA nephropathy; IQR, interquartile range; MPGN, membranoproliferative glomerulonephritis.
Progressor patients was defined as CKD stage 4 or 5 at 12 months.