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. 2024 May 3;30(5):e14737. doi: 10.1111/cns.14737

FIGURE 1.

FIGURE 1

Chronic administration of CBD inhibits METH‐induced CPP reinstatement in mice. (A) CPP test and RNA sequencing protocols. (B) Heat maps of mice's track in the CPP apparatus. (C) Administration of CBD (40 mg/kg, but not 20 mg/kg) during the 14‐day extinction phase inhibited METH‐induced CPP reinstatement in mice. *p < 0.05, ***p < 0.001 versus Pre‐conditioning test; ## p < 0.01, ### p < 0.001 versus Training test; & p < 0.05 versus METH group. Data were analyzed by two‐way ANOVA followed by Tukey's multiple comparison test, and all values are presented as the mean ± SEM (n = 7–8).