Skip to main content
. 2024 May 3;30(5):e14737. doi: 10.1111/cns.14737

FIGURE 3.

FIGURE 3

Chronic administration of CBD alleviates METH‐induced moods and cognitive impairments in mice. (A) Heat map of mice's track in the EPM apparatus. (B) Chronic administration of CBD increased the time spent in the open arms in METH‐treated mice. *p < 0.05; ## p < 0.01. (C) Both CBD and METH treatment do not affect the number of entries into the open arms in mice. n.s: not significant. (D) Heat maps of mice's track in the three‐chamber apparatus. (E) Chronic administration of CBD improved the reduction of the social ability index (%) caused by METH in mice. ***p < 0.001; ## p < 0.01. (F) Both CBD and METH treatment do not affect the social novelty index (%) in mice. n.s, not significant. (G) Heat map of mice's track in the Y maze apparatus. (H) Chronic administration of CBD (40 mg/kg, but not 20 mg/kg) rescued the reduction of the alteration triplet (%) induced by METH in mice. **p < 0.01; # p < 0.05. (I) Chronic administration of CBD (40 mg/kg, but not 20 mg/kg) decreased the immobility time of METH‐treated mice in the TST test. *p < 0.05; ## p < 0.01. (J) Chronic administration of CBD decreased the immobility time of METH‐treated mice in the FST test. **p < 0.01; # p < 0.05, ## p < 0.01. All data were analyzed by one‐way ANOVA followed by Tukey's multiple comparison test; all values are presented as the mean ± SEM; n = 6–8.