Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 4;29:269. doi: 10.1186/s40001-024-01856-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — Impact of HHT on apoptosis induction in CML. HHT disrupts the BCR–ABL oncogenic signaling in CML, leading to the inhibition of the Heat Shock Protein 90 (HSP90) chaperone function. This disruption contributes to the downregulation of Myeloid Cell Leukemia 1 (MCL-1) and upregulation of NOXA, both of which are key regulators of apoptosis. Furthermore, the figure depicts the increase in Bcl-2-associated X Protein (Bax) and the activation of BAK, triggering the apoptosis cascade. The combination of HHT with other cytotoxic agents is shown to result in a synergistic effect, enhancing the apoptotic response in CML cells. Abbreviations and symbols: HHT: Homoharringtonine; CML: Chronic Myeloid Leukemia; BCR–ABL: Breakpoint Cluster Region–Abelson; HSP90: Heat Shock Protein 90; MCL-1: Myeloid Cell Leukemia 1; NOXA: Latin for “damage,” a pro-apoptotic Bcl-2 family member; Bax: Bcl-2-associated X Protein; BAK: Bcl-2 homologous antagonist/killer; ↑: Increase/upregulation; ↓: Decrease/downregulation; X: Inhibition/blockage.