Figure 7.

Nucleotides at the 14 positions in the selected coreMix variants after six rounds of the selection cycle. Mixed bases were introduced at the positions in the initial pool. Nucleotides from the Azoarcus or Synechococcus ribozymes are indicated as red or blue, respectively. The following symbols indicate the relative activity: ++++, >70% activity of the sP2 form of coreAzo-4; +++, 40–70% activity of the sP2 form of coreAzo-4; ++, 10–40% activity of the sP2 form of the coreAzo-4; +, ∼10% activity of the sP2 form of coreAzo-4; –, no activity detected; n.d., not determined.