TABLE 1.
Genome-wide significant independent SNPs and loci for AD and frailty.
| Locus | Lead SNP | Gene/cytoband | CHR:BP | A1:A2 | RE2 p | AD m | Frailty m | AD p | Frailty p | AD z | Frailty z |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs and loci reaching genome-wide significance after meta-analysis of AD and frailty index (FI) | |||||||||||
| 1 | rs35096827 | CLRN1-AS1/3q25.1 | 3:150616348 | T:C | 2.09E-08 | 0.9 | 1 | 3.43E-02 | 8.58E-08 | −2.11 | −5.36 |
| RP11-166N6.2/3q25.1 | |||||||||||
| 2 | rs2071689 | GRK4/4p16.3 | 4:3039311 | T:C | 2.52E-08 | 0.9 | 1 | 1.89E-02 | 1.57E-07 | 2.36 | 5.18 |
| 3 | rs9471333 | LRFN2/6p21.2 | 6:40362023 | T:C | 3.47E-08 | 0.9 | 1 | 4.08E-02 | 2.71E-07 | −2.05 | −5.18 |
| 4 | rs11039165 | MADD/11p11.2 | 11:47312689 | A:G | 3.77E-08 | 1 | 0.1 | 2.26E-07 | 9.60E-04 | −5.17 | −3.32 |
| 5 | rs117500469 | RP11-368P15.1/14q22.1 | 14:53428839 | A:G | 4.48E-10 | 1 | 1 | 1.20E-06 | 5.01E-05 | 4.85 | 4.06 |
| FERMT2/14q22.1 | |||||||||||
| 6 | rs1635298 | CRHR1/17q21.31 | 17:43744344 | A:T | 1.84E-08 | 1 | 0.9 | 1.44E-05 | 1.60E-04 | 4.34 | 3.77 |
| 7 | rs28483960 | ZNF652/17q21.33 | 17:47432879 | T:C | 3.33E-09 | 0.9 | 0.7 | 2.90E-07 | 6.97E-05 | 5.15 | 4.00 |
| 8 | rs11660554 | LINC01929/18q21.2 | 18:52796510 | A:G | 2.39E-08 | 0.9 | 1 | 2.57E-03 | 6.90E-07 | 3.01 | 4.94 |
| RNA5SP459/18q21.2 | |||||||||||
| SNPs and loci reaching genome-wide significance after meta-analysis of AD and frailty phenotype (FP) | |||||||||||
| 1 | rs6722241 | AFF3/2q11.2 | 2:100803778 | T:C | 1.96E-08 | 0.9 | 1 | 4.64E-02 | 6.70E-08 | −5.08 | 4.43 |
| LINC01104/2q11.2 | |||||||||||
| 2 | rs2515933 | GRK4/4p16.3 | 4:3027897 | C:G | 3.38E-08 | 0.9 | 1 | 4.24E-02 | 9.70E-08 | −2.05 | −5.44 |
| 2 | rs10012797 | RGS12/4p16.3 | 4:3385176 | A:G | 2.54E-08 | 0.9 | 1 | 8.33E-03 | 1.60E-07 | 2.86 | 5.16 |
| 3 | rs34647879 | MAD1L1/7p22.3 | 7:1960646 | A:G | 1.40E-08 | 0.9 | 1 | 1.06E-02 | 6.80E-08 | 1.96 | −5.49 |
| 4 | rs11039307 | C1QTNF4/11p11.2 | 11:47611152 | T:C | 1.69E-09 | 0.9 | 0.5 | 3.77E-07 | 8.10E-06 | −2.03 | −5.37 |
| FAM180B/11p11.2 | |||||||||||
| 5 | rs1785498 | ZDHHC5/11q12.1 | 11:57448932 | T:C | 1.53E-08 | 0.9 | 1 | 4.03E-02 | 5.90E-08 | 1.99 | 5.42 |
| 6 | rs34342224 | CLEC16A/16p13.13 | 16:11225441 | T:C | 2.81E-08 | 0.9 | 1 | 4.26E-03 | 2.00E-07 | 2.03 | 5.29 |
| 7 | rs35733741 | FBXL19/16p11.2 | 16:30945887 | A:T | 1.22E-08 | 0.9 | 1 | 4.99E-02 | 5.10E-08 | −2.64 | −5.23 |
| 8 | rs34979937 | ZNF521/18q11.2 | 18:22690663 | A:G | 2.37E-08 | 0.9 | 1 | 4.25E-02 | 8.60E-08 | −2.55 | 5.36 |