TABLE 2.
Colocalization analysis on the meta-analysis significant loci between Alzheimer’s disease and frailty.
| Locus | NSNP | CHR | Start | Stop | PPA_1 | PPA_2 | PPA_3 | PPA_4 |
|---|---|---|---|---|---|---|---|---|
| Pairwise analysis between Alzheimer’s disease and frailty index | ||||||||
| 1 | 2680 | chr3 | 150252004 | 151348193 | 8.60E-04 | 6.37E-01 | 2.79E-02 | 3.18E-01 |
| 2 | 2751 | chr4 | 2844641 | 3844625 | 3.30E-07 | 7.51E-01 | 1.13E-02 | 2.38E-01 |
| 3 | 5,045 | chr6 | 40345542 | 42038449 | 4.17E-03 | 3.43E-05 | 8.24E-04 | 9.95E-01 |
| 4 | 6,212 | chr11 | 47008125 | 49865926 | 1.06E-01 | 1.33E-05 | 2.44E-02 | 8.69E-01 |
| 5 | 6,151 | chr14 | 51493572 | 53473918 | 3.83E-02 | 1.62E-01 | 1.54E-02 | 7.02E-01 |
| 6 | 6,406 | chr17 | 43056905 | 45874715 | 4.35E-03 | 4.30E-01 | 1.21E-02 | 5.20E-01 |
| 7 | 4076 | chr17 | 45876022 | 47516523 | 1.66E-03 | 5.67E-01 | 1.70E-01 | 2.22E-01 |
| 8 | 8,459 | chr18 | 51554436 | 55213381 | 9.31E-04 | 6.75E-01 | 4.40E-02 | 2.58E-01 |
| Pairwise analysis between Alzheimer’s disease and frailty phenotype | ||||||||
| 1 | 7,275 | chr2 | 98995201 | 101822144 | 5.04E-08 | 4.69E-01 | 5.08E-02 | 4.81E-01 |
| 2 | 3,075 | chr4 | 2845274 | 3845571 | 3.64E-12 | 2.94E-01 | 4.62E-01 | 2.45E-01 |
| 3 | 2557 | chr7 | 1354471 | 2061783 | 8.80E-09 | 3.96E-01 | 1.14E-01 | 4.91E-01 |
| 4 | 7,878 | chr11 | 47008125 | 49865926 | 4.67E-03 | 2.16E-07 | 7.53E-01 | 2.43E-01 |
| 5 | 12262 | chr11 | 55082693 | 58455737 | 1.11E-06 | 6.00E-01 | 4.54E-02 | 3.54E-01 |
| 6 | 4118 | chr16 | 10426040 | 11519750 | 1.08E-03 | 2.59E-01 | 4.88E-01 | 2.39E-01 |
| 7 | 2977 | chr16 | 29038452 | 31379355 | 6.37E-05 | 1.65E-01 | 3.38E-02 | 8.01E-01 |
| 8 | 5,500 | chr18 | 20649667 | 22994310 | 4.86E-05 | 5.98E-01 | 4.13E-02 | 3.59E-01 |
NSNP: number of Single nucleotide polymorphisms, CHR: chromosome, PPA_1: the probability that the locus is associated with AD, only, PPA_2: the probability that the locus is associated with frailty only, PPA_3: the probability that the locus is associated with both traits, PPA_4: the probability that the locus is associated with both traits but through different causal variants.