TABLE 3.

Summary of Mendelian randomization analysis results between Alzheimer’s disease and frailty.

Exposure	Outcome	Method	# SNPs	b	se	p
Mendelian randomization between Alzheimer’s disease and frailty index
FI	AD	MR Egger	15	1.73	1.08	0.13
		Weighted median	15	−0.11	0.20	0.59
		Inverse variance weighted	15	−0.13	0.15	0.37
		Simple mode	15	0.23	0.36	0.53
		Weighted mode	15	0.15	0.39	0.70
AD	FI	MR Egger	22	−0.03	0.03	0.33
		Weighted median	22	−0.01	0.01	0.35
		Inverse variance weighted	22	−0.01	0.01	0.32
		Simple mode	22	0.00	0.02	0.89
		Weighted mode	22	−0.01	0.02	0.42
Mendelian randomization between Alzheimer’s disease and frailty phenotype
FP	AD	MR Egger	36	0.99	0.80	0.22
		Weighted median	36	−0.15	0.22	0.51
		Inverse variance weighted	36	−0.22	0.20	0.26
		Simple mode	36	−0.18	0.45	0.68
		Weighted mode	36	−0.22	0.40	0.59
AD	FP	MR Egger	27	−0.01	0.37	0.97
		Weighted median	27	−0.03	0.02	0.12
		Inverse variance weighted	27	−0.03	0.02	0.09
		Simple mode	27	−0.03	0.31	0.93
		Weighted mode	27	−0.03	0.03	0.38

AD: Alzheimer’s disease, FI: frailty index, FP: frailty phenotype, b: beta, se: standard error, p: p-value.