Table 3.

Approved drugs with active assay results found in SMACC.

	Compound Information				Active Assay Results in SMACC
Drug name	Brand name	Approved clinical use	Inhibitory MOA	ChEMBL ID	Phenotypic Assay	Target-Based Assay
Simeprevir	Olysio®	HCV	NS3/NS4B Protease	CHEMBL501849		H7N7 Matrix Protein 2
Asunaprevir	Sunvepra®	HCV	Protease	CHEMBL2105735		H7N7 Matrix Protein 2
Sofosbuvir	Sovaldi®	HCV	NS5B	CHEMBL1259059	Dengue Virus
Ribavirin	Copegus®	HCV, RSV, fever	RdRp	CHEMBL1643	HPIV-3, Sandfly Fever, Dengue Virus, Yellow Fever Virus, RSV
Lopinavir	Kaletra®	HIV	Protease	CHEMBL729	SARS-CoV-2
Nelfinavir	Viracept®	HIV	Protease	CHEMBL584	Dengue Virus
Raltegravir	Isentress®	HIV	Integrase	CHEMBL254316		H7N7 Matrix Protein 2
Elvitegravir	Vitekta ®	HIV	Integrase	CHEMBL204656		SARS-CoV-2 3CLpro
Atazanavir	Reyataz®	HIV	Protease	CHEMBL1163		SARS-CoV-2 3CLpro
Rilpivirine	Edurant®	HIV-1	Nonnucleoside reverse transcriptase	CHEMBL175691	SARS-CoV-2
Podofilox	Condylox®	HPV-related diseases	Cytotoxicity/cell division	CHEMBL61	SARS-CoV-2
Trifluridine	Viroptic®	HSV	Viral and cellular DNA synthesis	CHEMBL1129	HPIV-3
Idoxuridine	Dendrid®	HSV-1	Viral and cellular DNA synthesis	CHEMBL788		Zika NS5
Acyclovir	Zovirax ®	HSV, VZV	Viral DNA polymerase	CHEMBL184		H7N7 Neuraminidase
Zanamivir	Relenza®	Influenza A and B	Neuraminidase	CHEMBL222813	H7N7