Table 1. Initial adduct levels.
Genotype | Average number of adducts/cell |
||
---|---|---|---|
3MeA | 7MeG | O6MeG | |
Aag+/+ | 1.2 × 105 | 3.5 × 106 | 2.6 × 105 |
Aag–/– | 2.2 × 105 | 4.1 × 106 | 2.4 × 105 |
Aag+/+ and Aag–/– mouse ES cells were exposed to [3H]MNU and subsequently assayed for 3MeA, 7MeG and O6MeG as described in Materials and Methods. Calculations are based on an average of 1.5n DNA content. All values are approximated from the average of between three and six experiments.