Table 11. Correlations between GTV, GTV D50%, and GTV – 2 mm DV-0.01 in four specific dose prescriptions based on BED in 5 fractions.
The specific dose prescriptions followed the 5-fraction examples shown in Table 4
GTV: gross tumor volume; DX%: a minimum dose covering at least X% of a target volume; GTV – 2 mm: GTV evenly reduced by 2 mm; DV-0.01 cc: a minimum dose to cover a target volume minus 0.01 cc; BED: biologically effective dose; GTV + X mm: GTV evenly expanded by X mm; BED10: biologically effective dose based on the linear-quadratic model with an alpha/beta ratio of 10; vs: versus
| Dose prescription | GTV D50% (range, BED10) | Spearman’s rho (vs GTV) (P value) | GTV – 2 mm DV-0.01 cc (range, BED10) | Spearman’s rho (vs GTV) (P value) | Spearman’s rho (GTV D50% vs DV-0.01 cc) (P value) |
| GTV D98% | 115.1-123.5 Gy | 0.775 (P = 0.041 *) | 108.2-134.4 Gy | -1.000 | -0.775 (P = 0.041 *) |
| GTV DV-0.01 cc | 117.0-132.9 Gy | 0.857 (P = 0.014 *) | 116.5-136.5 Gy | -1.000 | -0.857 (P = 0.014 *) |
| GTV + 1 mm D95% | 95.8-108.0 Gy | -0.964 (P < 0.001 ***) | 88.3-124.3 Gy | -1.000 | 0.964 (P < 0.001 ***) |
| GTV + 2 mm D95% | 82.3-98.6 Gy | -0.847 (P = 0.016 *) | 59.5-73.0 Gy | -0.964 (P < 0.001 ***) | 0.883 (P = 0.009 **) |