Table 2.
Cox proportional hazards model for 3-month survival in patients with AE-IPF
| Variables | HR | 95%CI | P-value |
|---|---|---|---|
| Univariate analysis | |||
| Age, years | 1.007 | 0.948–1.070 | 0.810 |
| Sex, male | 0.863 | 0.257–3.894 | 0.830 |
| Smoking history, pack-years | 1.010 | 0.982–1.040 | 0.471 |
| WBC (/μL) | 1.000 | 0.999–1.000 | 0.051 |
| Neutrophil (%) | 1.066 | 1.007–1.142 | 0.025 |
| LDH (U/L) | 1.003 | 0.999–1.007 | 0.080 |
| CCr (mL/min) | 0.972 | 0.934–1.001 | 0.062 |
| CRP (mg/dL) | 1.050 | 0.978–1.119 | 0.169 |
| LCN2 ≥ 86.1 ng/mL | not availablea | not availablea | 0.004 |
| Multivariate analysis | |||
| LCN2 ≥ 86.1 ng/mL | not availablea | not availablea | 0.019 |
| Neutrophil (%) | 1.053 | 0.987–1.131 | 0.121 |
AE Acute exacerbation, IPF Idiopathic pulmonary fibrosis, HR Hazards ratio, CI Confidence interval, WBC White blood cell, LDH Lactate dehydrogenase, CCr Creatinine clearance, CRP C-reactive protein, LCN2 Lipocalin-2
aHR and 95%CI could not be calculated because there was no mortality in the low LCN2 (< 86.1 ng/mL) group