Table 4.
Multivariate competing risk analyses* for risk for all-cause mortality, transplant waitlist, and decompensation.
| All-cause Mortality |
Transplant Waitlist |
Decompensation |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Risk Factor | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Income | |||||||||
| Per capita income for every $10,000 increase | 0.96 | 0.94–0.98 | <0.001 | 1.08 | 1.05–1.12 | <0.001 | 1.00 | 1.00–1.00 | <0.001 |
| Median family income in US dollars per $10,000 increase | 0.98 | 0.97–1.00 | 0.022 | 1.12 | 1.09–1.14 | <0.001 | 1.00 | 1.00–1.00 | <0.001 |
| % Families below federal poverty level per 10% increase | 1.03 | 0.99–1.06 | 0.150 | 0.62 | 0.57–0.68 | <0.001 | 1.00 | 1.00–1.01 | 0.002 |
| Income disparity per 0.1 increase of Gini Index | 0.93 | 0.88–0.98 | <0.01 | 0.73 | 0.65–0.81 | <0.001 | 0.76 | 0.50–1.17 | 0.217 |
| Education | |||||||||
| % Population aged 25 years or older with less than 9 years of education per 10% increase | 1.02 | 0.98–1.05 | 0.340 | 0.72 | 0.67–0.78 | <0.001 | 1.00 | 1.00–1.01 | 0.029 |
| % Population aged 25 years or older with at least a high school diploma per 10% increase | 1.06 | 1.03–1.10 | <0.001 | 0.98 | 0.92–1.05 | 0.601 | 1.01 | 1.00–1.01 | <0.001 |
| % Civilian labor force population aged 16 years and older who are unemployed per 10% increase | 1.17 | 1.05–1.31 | <0.01 | 0.65 | 0.49–0.84 | <0.001 | 1.01 | 1.00–1.02 | 0.169 |
| Social Support | |||||||||
| % Single-parent households with children younger than 18 per 10% increase | 1.02 | 1.00–1.04 | 0.031 | 0.80 | 0.76–0.84 | <0.001 | 1.00 | 1.00–1.00 | 0.002 |
| Housing Conditions | |||||||||
| Median home value in US dollars per $10,000 | 0.97 | 0.96–0.99 | <0.001 | 1.01 | 0.98–1.04 | 0.640 | 1.00 | 1.00–1.00 | <0.001 |
| Median gross rent in US dollars per $1,000 | 0.61 | 0.47–0.80 | <0.001 | 2.38 | 1.48–3.83 | <0.001 | 1.00 | 1.00–1.00 | <0.001 |
| Median monthly mortgage in US dollars per $1,000 | 0.87 | 0.81–0.93 | <0.001 | 1.01 | 0.88–1.15 | 0.917 | 1.00 | 1.00–1.00 | <0.001 |
| % Owner-occupied housing units per 10% increase | 1.00 | 0.98–1.02 | 0.906 | 1.23 | 1.18–1.28 | <0.001 | 1.00 | 1.00–1.00 | 0.603 |
| % Households with more than 1 person per room per 10% increase | 0.96 | 0.87–1.07 | 0.466 | 0.43 | 0.34–0.55 | <0.001 | 1.00 | 0.99–1.01 | 0.532 |
| % Households without a motor vehicle per 10% increase | 0.96 | 0.93–0.99 | 0.020 | 0.66 | 0.59–0.75 | <0.001 | 1.00 | 1.00–1.00 | 0.772 |
| % Occupied housing units without complete plumbing per 10% increase | 0.98 | 0.85–1.14 | 0.802 | 0.15 | 0.08–0.26 | <0.001 | 1.02 | 1.01–1.03 | 0.004 |
sHR = subdistribution hazard ratio, CI = confidence interval
*
Controlled for age, race, gender, insurance status, etiology of cirrhosis (HCV, HBV, alcohol, MASH, cholestasis), decompensation status (ascites, HE, esophageal varices, variceal bleeding, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome), HCC, MELD-Na, Charlson Comorbidity Index
**
A new model was constructed for each individual SDOH covariate and this table is an aggregate of multiple models. ADI and each individual SDOH risk factor was included into the model separately while adjusting for clinicodemographic covariates.