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. 2024 Apr 22;15:1375340. doi: 10.3389/fimmu.2024.1375340

Figure 4.

Figure 4

DMF reduces the inflammatory markers in the lungs of the allergic asthma model. (A–C) RT-qPCR was performed to analyze the mRNA expression of Th2 inflammatory cytokines IL4 (A) and IL13 (B) and Th17 cytokine IL17 (C) in the lungs of OVA-induced mice with or without DMF treatment. (D–F) ELISA was performed to evaluate the protein expression of Th2 inflammatory cytokines IL4 (D) and IL13 (E) and Th17 cytokine IL17 (F) in the lungs of OVA-induced mice with or without DMF treatment. (G) RT-qPCR was performed to determine the mRNA expression of anti-inflammatory cytokine IL10 in the lungs of OVA-induced mice with or without DMF treatment. (H) ELISA was performed to determine the protein expression of anti-inflammatory cytokine IL10 in the lungs of OVA-induced mice with or without DMF treatment. (I) RT-qPCR was performed to determine the mRNA expression of Foxp3 in the lungs of OVA-induced mice with or without DMF treatment. All other data are shown as the mean ± SEM (n = 6 per group). #P < 0.05 versus the control group. ***P < 0.001, **P < 0.01, *P < 0.05 vs OVA group. OVA, Ovalbumin. DMF, dimethyl fumarate.