Table 3.
Association between ANA positivity and the incidence risk of RA in the propensity-score matched cohort*.
| Variables | Non-adjusted | Adjusted I | ||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| ANA titers | ||||
| Negative | Reference | Reference | ||
| 1:100 | 3.95 (3.02, 5.17) | <0.0001 | 3.95 (3.01, 5.18) | <0.0001 |
| 1:320 | 16.69 (9.49, 29.37) | <0.0001 | 16.63 (9.44, 29.30) | <0.0001 |
| 1:1,000 | 17.49 (9.62, 31.79) | <0.0001 | 17.34 (9.53, 31.54) | <0.0001 |
| ANA patterns | ||||
| Negative | Reference | Reference | ||
| Nuclear homogeneous | 16.89 (11.53, 24.74) | <0.0001 | 16.81 (11.46, 24.65) | <0.0001 |
| Nuclear speckled | 3.42 (2.51, 4.64) | <0.0001 | 3.40 (2.49, 4.63) | <0.0001 |
| Centromere | 4.17 (0.69, 25.25) | 0.1198 | 4.19 (0.69, 25.36) | 0.1198 |
| Nucleolar | 1.62 (0.82, 3.23) | 0.1680 | 1.62 (0.81, 3.23) | 0.1683 |
| Cytoplasmic speckled | 3.09 (1.77, 5.39) | <0.0001 | 3.09 (1.77, 5.40) | <0.0001 |
| Other patterns | 3.25 (1.07, 9.83) | 0.0373 | 3.24 (1.07, 9.82) | 0.0377 |
*The propensity-score matched cohort included 598 patients in the RA group and 598 patients in the non-RA group.
RA, rheumatoid arthritis; ANA, antinuclear antibody; OR, odds ratio; 95% CI, 95% confidence interval.
Adjusted I: Adjusted for age, sex.