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Pulmonary langerhans cell histiocytosis. (A,B) A cellular infiltrate is comprised of numerous eosinophils and large cells. (C) The large cells (Langerhans cells) have round to oval nuclei that contain grooves or folds or are wrinkled with conspicuous or inconspicuous nucleoli. (D) The large cells express CD1a, a hallmark feature of PHLC. Magnification: H&E ×10 (A), ×400 (B–D).
