TABLE 2.

Microphysiological systems for tumor-stromal-immune study of pancreatic ductal adenocarcinoma.

Cancer model	Reference	Key features	Cell types	Key findings
PDAC	Haque et al. (2022)	Device with 2 chambers separated by porous membrane, pump	Patient-derived PDAC organoids, PSCs and macrophages	Anti-stromal compounds enhance PDAC chemotherapy response in tumor chip
PDAC	Mollica et al. (2021)	Microfluidic device with 2 lateral channels and central chamber	ECs, PSCs, Panc-1 PDAC cells, and T cells	EC barrier decreases T cell infiltration into PSCs + Panc-1
PDAC	Lee et al. (2020)	Microfluidic chip with 4 connected channels	Panc-1 PDAC cells and macrophages	Interstitial flow and cancer cell signaling increases macrophage motility