Table 2.
Hemostasis analysis in control rats (C), diabetic rats (DC), diabetic rats treated with subcutaneous insulin (SC Ins), and diabetic rats treated with oral insulin loaded in nCOFs (OG Ins).
| Tests | C | DC | SC Ins | OG Ins |
|---|---|---|---|---|
| Quick time (s) | 15.1 ± 0.5 | 15.2 ± 0.7 | 15.3 ± 0.9 | 14.3 ± 0.6 |
| APTT (s) | 25.3 ± 1.0 | 24.2 ± 1.2 | 23.9 ± 3.1 | 23.9 ± 2.1 |
| Factor II (%) | 97.7 ± 1.1 | 85.6 ± 4.0 | 80.4a* ± 12.7 | 109.9b† ± 11.9 |
| Factor V (%) | 99.0 ± 0.7 | 98.3 ± 2.4 | 99.6 ± 1.1 | 100.4 ± 1.5 |
| Factor VII (%) | 80.0 ± 1.2 | 79.7 ± 1.8 | 79.6 ± 1.1 | 79.8 ± 1.3 |
| Factor VIII (%) | 118.7 ± 32.0 | 294.3a† ± 42.6 | 330.0a† ± 0.0 | 211.5a,b* ± 68.8 |
| Factor IX (%) | 116.4 ± 1.3 | 110.4 ± 12.3 | 203.8a,b* ± 18.8 | 146.7 ± 74.8 |
| Factor X (%) | 86.2 ± 2.4 | 94.2 ± 21.2 | 104.7 ± 3.7 | 150.7a,b† ± 5.5 |
| Fibrinogen (mg/d) | 249.1 ± 28.5 | 369.4a† ± 32.2 | 555.8a,b† ± 47.7 | 289.0b* ± 24.8 |
| d-dimer (μg/ml) | 0.33 ± 0.02 | 0.42a* ± 0.01 | 0.43a* ± 0.08 | 0.32b* ± 0.01 |
Results are expressed as mean ± SEM
(*p < 0.05); (†p < 0.001).
a
versus C,.
b
versus DC..