Figure 7.

Synergies between dNKAP depletion and oncogenic form of Ras, Notch, or Yki in promoting tumorigenic growth. (A–H’) Ectopic expression of Ras^V12, NICD, or Yki^S168A in dNKAP-knockdown tissues induces massive tissue overgrowth. GFP was used to mark the knockdown domain. Shown are single confocal sections of third-instar wing imaginal discs with dorsal side up. Scale bar, 100 μm. (I) Quantification of GFP-positive area in wing discs with the indicated genotypes. n = 15, 13, 21, 16, 9, 12, 15, and 15 for each genotype, respectively. The value was calculated by normalizing to the mean area of the control disc. **P < 0.01.