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. 2024 Apr 30;45:101934. doi: 10.1016/j.tranon.2024.101934

Fig. 7.

Fig. 7

ESCC cells-derived exosomal NAT10 regulates macrophage M2 polarization in an FASN-dependent manner A. FASN was knocked out in macrophages. B, C. The M2 polarization of macrophages, promoted by NAT10 overexpression, was reversed by FASN knockout, as determined by RT-qPCR and flow cytometry. D. The M1 polarized macrophages suppressed by NAT10 overexpression were restored by FASN knockout, as determined by flow cytometry. E, F. The effects of FASN knockout on ESCC cells-derived exosomes-mediated macrophage M2 polarization were assessed by RT-qPCR and flow cytometry. G. The effects of FASN knockout on ESCC cells-derived exosomes-mediated macrophage M1 polarization were examined by flow cytometry. ⁎⁎P < 0.01.