eTable 2.

Risk of Dementia and Subtypes by Sex

	Hazard Ratio (95% Confidence Interval)
	Men		Women
Dementia Status	Model 1a	Model 2b	Model 1a	Model 2b
Total Dementia (n=2547 [1503 Women, 1044 Men])
Diabetes only	1.52 (0.95–2.42)	1.43 (0.89–2.30)	1.34 (0.84–2.16)	1.43 (0.88–2.32)
APOE ε4 only	1.55 (1.06–2.26)	1.59 (1.08–2.34)	2.47 (1.86–3.26)	2.47 (1.86–3.29)
Bothc	3.05 (1.62–5.75)	2.38 (1.24–4.54)	3.88 (1.87–8.05)	4.72 (2.23–10.0)
AD (n=2343 [1394 Women, 949 Men]) d
Diabetes only	1.85 (0.88–3.91)	1.87 (0.88–4.00)	1.31 (0.67–2.55)	1.53 (0.77–3.04)
APOE ε4 only	2.32 (1.33–4.04)	2.57 (1.44–4.56)	2.82 (1.95–4.09)	2.78 (1.91–4.04)
Bothe	4.90 (2.13–11.27)	4.78 (2.02–11.30)	4.94 (1.95–12.49)	5.95 (2.29–15.5)
Mixed AD (n=2268 [1332 Women, 936 Men]) d
Diabetes only	1.53 (0.70–3.34)	1.37 (0.62–3.06)	2.10 (0.96–4.56)	2.06 (0.91–4.68)
APOE ε4 only	1.30 (0.65–2.59)	1.25 (0.63–2.52)	3.56 (2.14–5.95)	3.55 (2.10–5.99)
Bothc	3.52 (1.06–11.72)	2.19 (0.62–7.64)	7.80 (2.30–26.42)	10.37 (2.94–35.53)
VaD (n=2194 [1283 Women, 911 Men]) f
Diabetes only	0.89 (0.26–3.00)	0.80 (0.23–2.75)	1.02 (0.23–4.42)	0.93 (0.20–4.42)
APOE ε4 only	1.06 (0.42–2.65)	1.04 (0.41–2.63)	0.80 (0.27–2.35)	0.79 (0.25–2.37)
Bothe	1.28 (0.17–9.71)	0.55 (0.07–4.45)	NE	NE

Abbreviations: AD, Alzheimer disease; APOE ε4, ε4 allele of the apolipoprotein E genotype; NE, not estimable due to small sample size; VaD, vascular dementia.

^aAdjusted for age and years of education.

^bAdjusted for age, years of education, hypertension, total cholesterol, smoking, alcohol, race, body mass index, depression status, ankle-brachial index, and stroke.

^cCross-product between diabetes/APOE ε4 subgroups and sex, P>.1. The analysis was adjusted as in model 1.

^dExcluded participants with VaD and other types of dementia.

^eCross-product between diabetes/APOE ε4 subgroups and sex, P>.2. The analysis was adjusted as in model 1.

^fExcluded participants with AD and other types of dementia.