Table 1. The clinical characteristics of the four patients with IFS analyzed in this study.
| Patient ID | Gender | Age at onset | Clinical manifestations | Local lesion | Other lesions | Surgery | Histopathological characteristics | ETV6-NTRK3 gene fusion | IRS staging | Follow-up | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Site | Diameter at diagnosis (cm) | Diagnosis | IHC | |||||||||
| Patient 1 | M | After birth | Vomit | Abdominal and pelvic cavity | 8.80 | No | Biopsy | IFS | Vimentin (+), Ki-67 30% (+), alpha-SMA (−), CD34 (−), S-100 (−), Desmin (−) |
Yes | III | Dead |
| Patient 2 | M | 2 months old | Painless lump | From the pelvic area to the right buttock | 1.30 | No | Biopsy | IFS | Vimentin (+), Ki-67 40% (+), alpha-SMA (+), CD34 (−), S-100 (−), Desmin (−) |
Yes | III | Survival |
| Patient 3 | F | After birth | Right eye protrusion | Behind the right eyeball | 3.50 | No | Resection | IFS | Vimentin (+), Ki-67 20% (+), alpha-SMA (−), CD34 (−), S-100 (−), Desmin (−) |
Yes | II | Survival |
| Patient 4 | M | After birth | Vomit and bilateral lower limb swelling | From the pelvic area to the right buttock | 6.00 | No | Biopsy | IFS | Vimentin (+), Ki-67 15% (+), alpha-SMA (+), CD34 (−), S-100 (+), Desmin (−) |
Yes | III | Survival |
IFS, infantile fibrosarcoma; M, male; F, female; cm, centimeter; IHC, immunohistochemistry; SMA, smooth muscle action; IRS, intergroup rhabdomyosarcoma study.