Table 2. The clinical characteristics of validation cohort with IFS in this study.
| Patient ID | Gender | Age at onset | Clinical manifestations | Local lesion | Surgery | Diagnosis | IHC | ETV6-NTRK3 gene fusion | IRS staging | Follow-up | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Site | Diameter at diagnosis (cm) | CTHRC1 | POSTN | IGFBP2 | |||||||||
| Patient 4 | M | After birth | Painless lump | Head | 9.38 | Resection | IFS | (+) | (+) | (+) | Yes | I | Survival |
| Patient 5 | M | After birth | Painless lump | Head | 19.00 | Resection | IFS | (+) | (+) | (+) | No | I | Survival |
| Patient 6 | F | 2 months old | Painless lump | From the abdomen to the back | 8.92 | Resection | IFS | (+) | (+) | (+) | No | III | Survival |
| Patient 7 | M | After birth | Painless lump | From left shoulder joint to the back | 5.40 | Resection | IFS | (+) | (+) | (−) | No | III | Survival |
| Patient 8 | M | After birth | Painless lump | Head | 1.73 | Resection | IFS | (+) | (+) | (+) | No | I | Survival |
| Patient 9 | F | 7 days old | Painless lump | Right thigh | 5.60 | Biopsy | IFS | (+) | (+) | (+) | No | III | Survival |
| Patient 10 | F | 19 months old | Painless lump | Back | 2.14 | Resection | IFS | (+) | (+) | (+) | No | I | Survival |
| Patient 11 | F | 5 months old | Melena | Abdominal cavity | 3.50 | Resection | IFS | (+) | (+) | (−) | No | II | Survival |
| Patient 12 | F | 12 months old | Painless lump | Left foot | 5.29 | Resection | IFS | (-) | (+) | (+) | No | III | Survival |
| Patient 13 | M | 7 days old | Abdominal distention | Abdominal cavity | 8.55 | Resection | IFS | (+) | (+) | (+) | No | I | Survival |
| Patient 14 | F | After birth | Painless lump | Left calf | 5.60 | Biopsy | IFS | (+) | (+) | (+) | Yes | III | Survival |
| Patient 15 | M | After birth | Painless lump | Abdominal cavity | 6.60 | Resection | IFS | (+) | (+) | (+) | Yes | I | Survival |
| Patient 16 | F | 3 days old | Painless lump | Right thigh | 5.50 | Biopsy | IFS | (+) | (+) | (+) | Yes | IV (lung) | Survival |
| Patient 17 | M | 3 days old | Painless lump | Right thigh | 7.31 | Resection | IFS | (+) | (+) | (+) | No | I | Survival |
| Patient 18 | M | After birth | Painless lump | Right chest wall | 12.60 | Resection | IFS | (+) | (+) | (+) | No | II | Survival |
| Patient 19 | M | After birth | Painless lump | From the abdomen to the back | 5.60 | Resection | IFS | (+) | (−) | (+) | Yes | III | Survival |
| Patient 20 | M | 4 days old | Fever, vomit and poor appetite | Abdominal cavity | 2.50 | Resection | IFS | (+) | (+) | (+) | Yes | I | Survival |
| Patient 21 | M | 3 months old | Painless lump | Right thigh | 4.81 | Resection | IFS | (+) | (+) | (+) | Yes | III | Survival |
| Patient 22 | M | After birth | Abdominal distension and genitalia swelling | Abdominal cavity | 13.80 | Biopsy | IFS | (+) | (+) | (+) | No | III | Dead |
IFS, infantile fibrosarcoma; M, male; F, female; cm, centimeter; IHC, immunohistochemistry; IRS, intergroup rhabdomyosarcoma study.