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. 2023 Dec 29;41(1-2):59–72. doi: 10.1089/neu.2023.0046

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© Aaron M. Gusdon et al., 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 2. — Changes in lipid metabolites over time after injury. Volcano plots of 24 h (A) and 3-month (B) changes after mild traumatic brain injury (mTBI). Fold changes are depicted comparing mTBI to controls. Metabolites found to be significantly higher in subjects with good outcomes (1-linoleoyl-GPC [18:2], 1-linoleoyl-GPE [18:2], and 1-linolenoyl-GPC [18:3]) are shown in red. Levels of each metabolite are shown in C–E. Levels are shown early (within 24 h) and late (3 months) after injury for those with bad (Glasgow Outcome Scale [GOSE] ≤6, red) and good (GOSE ≥7, blue) outcomes. *p < 0.001.