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. 2023 Dec 29;41(1-2):59–72. doi: 10.1089/neu.2023.0046

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© Aaron M. Gusdon et al., 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Schematic overview of pathways involved. A diagram of the Kennedy and Lands Cycles is shown depicting the biosynthesis pathways of membrane phosphatidylcholine. Phospholipases remove an acyl group from phosphatidylcholine to produce lysophospholipids and free fatty acids (FFAs). Lysophospholipids can be combined with diverse acyl groups to generate phosphatidylcholine for membrane repair. FFAs, such as polyunsaturated fatty acids (PUFAs), removed from the sn-2 position of phosphatidylcholine may be used in downstream signaling pathways. An analogous pathway exists for phosphatidylethanolamine. Abbreviations: correlation (cor), lysophospholipid (LPL), phosphatidylcholine (PC), diacylglycerol (DAG), phospholipase A₂ (PLA₂), lysophospholipid acyltransferase (LPLAT).