Table 2.
Multivariable Models Assessing Associations Between Lysophospholipid Metabolites and Dichotomized GOSE Outcomes
| GOSE (discharge)a | GOSE (6-month)a | ||
|---|---|---|---|
| 1-linoleoyl-GPC (18:2) | Unadjusted | 8.75 (3.04, 30.3), p = 1.87 × 10−4 | 5.23 (1.87, 17.3), p = 3.11 × 10−3 |
| Adjusted | 12.2 (3.35, 58.3), p = 5.23 × 10−4 | 4.67 (1.49, 17.7), p = 0.013 | |
| Age | 0.958 (0.921, 0.993), p = 0.023 | 0.952 (0.913, 0.988), p = 0.013 | |
| Sex (male) | 1.87 (0.549, 6.65), p = 0.318 | 0.206 (0.025, 1.19), p = 0.286 | |
| Race (white) | 1.42 (0.247, 8.27), p = 0.692 | 0.206 (0.025, 1.19), p = 0.098 | |
| Ethnicity (Hispanic) | 1.71 (0.499, 6.18), p = 0.397 | 1.23 (0.358, 4.34), p = 0.738 | |
| HLD | 0.580 (0.152, 2.14), p = 0.413 | 1.97 (0.524, 8.17), p = 0.327 | |
| 1-linoleoyl-GPE (18:2) | Unadjusted | 4.94 (2.06, 13.4), p = 7.58 × 10−4 | 2.40 (1.07, 5.84), p = 0.041 |
| Adjusted | 9.43 (2.87, 39.6), p = 7.26 × 10−4 | 2.93 (1.11, 8.87), p = 0.039 | |
| Age | 0.954 (0.917, 0.988), p = 0.012 | 0.947 (0.909, 0.982), p = 5.53 × 10−3 | |
| Sex (male) | 2.44 (0.697, 9.23), p = 0.171 | 0.572 (0.152, 1.99), p = 0.388 | |
| Race (white) | 0.688 (0.107, 4.17), p = 0.683 | 0.153 (0.017, 0.949), P = 0.059 | |
| Ethnicity (Hispanic) | 1.80 (0.523, 6.50), p = 0.356 | 1.20 (0.358, 4.04), p = 0.770 | |
| HLD | 0.63 (0.168, 2.30), p = 0.481 | 2.16 (0.593, 8.83), p = 0.257 | |
| 1-linolenoyl-GPC (18:3) | Unadjusted | 4.60 (2.05, 12.2), p = 7.11 × 10−4 | 2.61 (1.26, 6.10), p = 0.015 |
| Adjusted | 5.26 (1.99, 16.7), p = 2.04 × 10−3 | 2.57 (1.08, 7.11), p = 0.046 | |
| Age | 0.964 (0.929, 0.998), p = 0.042 | 0.955 (0.918, 0.989), p = 0.016 | |
| Sex (male) | 1.78 (0.542, 6.01), p 0.344 | 0.585 (0.158, 2.01), p = 0.403 | |
| Race (white) | 0.769 (0.121, 4.81), p = 0.776 | 0.162 (0.018, 1.08), p = 0.07 | |
| Ethnicity (Hispanic) | 1.78 (0.528, 6.31), p = 0.355 | 1.30 (0.383, 4.47), p = 0.674 | |
| HLD | 0.630 (0.176, 2.23), p = 0.471 | 1.96 (0.543, 7.85), p = 0.317 |
Bold values represent significant p-values < 0.05.
a
Data are presented as odds ratio (OR) with 95% confidence interval (CI). Levels of each lysophospholipid were log10 transformed.
HLD, hyperlipidemia; GOSE, Glasgow Outcome Scale – Extended