Table 1.

Transcription factors enriched in binding to promoter regions of perturbed genes

TF	Function	Targeting group
CBX8	A key component of a Polycomb group (PcG) complex, essential for maintaining the transcriptionally repressive state of numerous genes	Down-regulated
EZH2	A Polycomb group (PcG) protein, it catalyzes the methylation of ‘Lys-9' (H3K9me) and ‘Lys-27' (H3K27me) on histone H3, leading to transcriptional repression of the target gene	RI
KAT8	A histone acetyltransferase that may be involved in transcriptional activation	RI
LEO1	A PAF1 complex component, plays multiple roles in development, maintenance of embryonic stem cell pluripotency, and transcriptional elongation	RI
TBP	Serves a central role in the DNA-binding multiprotein factor TFIID	RI
RARA	A nuclear retinoic acid receptor, the encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner	RI
USP7	This protein deubiquitinates different target proteins and plays important roles in DNA damage, cell growth, and apoptosis	RI
SALL1	A transcription factor involved in embryonic development	Up-regulated