Table 4.

The design scheme and test results of the Box–Behnken design.

Run numbers	X 1	X 3	X 6	Y 1	Y 2
				(1010 CFU/mL)	(mm/mL)
1	−1	−1	0	0.91	142.08
2	−1	1	0	1.54	146.10
3	1	1	0	0.84	140.77
4	0	0	0	1.99	153.97
5	1	−1	0	0.84	136.35
6	0	−1	1	0.76	135.31
7	0	−1	−1	0.93	142.28
8	1	0	1	0.54	134.21
9	0	0	0	1.85	151.18
10	0	1	1	1.21	145.68
11	−1	0	1	1.16	146.00
12	0	0	0	1.66	147.51
13	−1	0	1	1.16	144.03
14	1	0	−1	0.84	138.35
15	0	0	0	1.89	149.60
16	0	0	0	2.11	153.17
17	0	1	−1	1.01	142.74