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. 2024 May 6;17:13. doi: 10.1186/s13072-024-00528-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The dynamic model of fruit fly nucleus at TAD resolution. Starting from an initial arrangement of the chromosome arms (leftmost), the chromatin in control (upper row) and lamins depleted (bottom row) nuclei changes conformation as time progresses along the interphase. Shown are actual snapshots from the respective simulations and their corresponding approximate biological time points [45]. See supplementary movies of the chromosome arms motion: Additional files 2, 3, 4. Structural signatures, such as probability of a TAD to be in contact with the NE, are computed and averaged along each trajectory. Green spheres: L-TADs. Red spheres: NonL-TADs. The grey spherical shell next to the NE indicates the 0.2 $μ$ m contact zone