Qualitative review of the spheres (top), shapes (middle), and P22 (bottom) datasets across all methods (columns). Images are zoom insets of projections in the xz-plane. Both IMOD and EMAN2 suffer from back-projection artifacts. Compared to IsoNet, our method better resolves these artifacts and produces higher shape fidelity. Both IsoNet (tile pattern) and ours (horizontal streaks) can produce artifacts due to computational constraints, as discussed in Section 4. Figures A1, A2, A3 contain all projection directions and a larger field of view.