Figure 7. Effect of thyroid follicle ablation upon morphology and gene expression.
(A) In thyroid ablated adult zebrafish (hypothyroid) there is a significant shift in the position of the maxilla towards a more terminal position. (B) In hypothyroid individuals, there is a significant reduction in the distance from the dorsal-most position of the maxilla to the long-axis of the body. All distances are relative to the standard length. n = 11 for each condition. (C) In hypothyroid individuals, there is a significant increase of lepa expression in the head at 14dpf. n = 3 pools of 20 heads for each condition. (D) Plotting Principal Components 1 and 2 reveals significant differences in dentary shape (Proscrustes ANOVA F40;944=40.84 p˂0.0001) between morphs. Scale bar = 10mm.