Figure 3.

ROC curves for variables (a) absolute sNfL concentration (ng/L) at baseline in those less than 50 years old, (b) sNfL range (ng/L), (c) Z-score at baseline sNfL level, (d) Z-score at 5.5 weeks after relapse symptom onset, and Z-score at baseline (e) in those with MRI activity and (f) in those with relapse but no MRI activity. In controls, individual mean sNfL was used to calculate Z-scores in (c–f), and individual mean sNfL in controls aged less than 50 years old were used to calculate (a).

ROC: receiver operating characteristic; sNfL: serum neurofilament light; MRI: magnetic resonance imaging.