Table 1.

Baseline demographic and clinical characteristics

	CIS/RRMS study cohort (N = 44)	NEDA-3 controls (N = 66)
Age, median (IQR)	35 (27–40)	45 (37–52)	p < 0.001
Sex, female, N (%)	31 (71)	54 (82)	p = 0.165
Years since MS diagnosis, median (IQR)	0 (0–8)	10 (6–16)	p < 0.001
Time in days from relapse onset or CEL detection to sampling, mean (SD)	22 (20)	NA
Body mass index (kg/m2), median (IQR)	24 (21–30)N = 29	25 (19–56)N = 60	p = 0.746
EDSS, median (IQR)	2.0 (1.5–3.5)N = 44	2.0 (1.0–2.5)N = 66	p = 0.121

CIS: clinically isolated syndrome; RRMS: relapsing-remitting multiple sclerosis; NEDA-3: no evidence of disease activity; CEL: contrast-enhancing lesion; EDSS: Expanded Disability Status Scale; IQR: interquartile range; NA: not applicable; SD: standard deviation; MS: multiple sclerosis.