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Antitrypanosomal activity against T. cruzi epimastigotes and cytotoxicity of derivatives 19a,b.
| |||
|---|---|---|---|
| Compound |
IC50a
CL-Luc: Neon Clone Epim. |
IC50a
BSR Cells |
SIb |
| 19a | 11.1 ± 3.2 | 70.1 ± 9.6 | 6 |
| 19b | 24.8 ± 5.8 | 67.6 ± 6.1 | 3 |
| Benznidazole | 3.8 ± 0.7 | 191.28 ± 1.8 | 67 |
Note: aIC50 (µM): compound concentration that reduced the parasite load of 50%; bSI: selectivity index (IC50 BSR/IC50 parasite).
