. 2024 Feb 26;31(15):1955–1982. doi: 10.2174/0929867331666230915093928

Table 3.

Structures and antimalarial activity of benzimidazole derivatives 3a-e.


Compound	3D7 IC₅₀^a	Dd2 IC₅₀^a	^bCam3.II^rev IC₅₀^a	^cCam3.II^C580Y IC₅₀^a	Dd2-SJ Resistant IC₅₀^a
3a, R = H	77	97.3	350	264	46
3b, R = CH₃	42	31.7	140	81	17.5
3c, R = OCH₃	43	-	212	168	-
3d, R = 3,5-di-CH₃	23	-	133	139	-
3e, R = 4,5-di-OCH₃	6.4	-	47	63	-

Note: ^aIC₅₀ (nM): compound concentration that reduced the parasite load of 50%. ^bCam3.II line has a K13 R539T mutation that is in Cam3.II^rev was gene-edited to wild type K13 gene. ^cCam3.II lines bearing the C580Y mutation in the K13 gene, which is responsible for resistance to artemisinin.