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. 2024 Feb 26;31(15):1955–1982. doi: 10.2174/0929867331666230915093928

Table 5.

Example of benzimidazole phthalimide hybrids 5a-e and their antimalarial activity.

graphic file with name CMC-31-1955-T5.jpg
Compound 3D7 IC50a RKL-9 IC50a SIb
- R R1 R2 - - -
5a CH3 CH2CH(CH3)2 4-Cl-phenyl 0.74 1.71 >135 >675
5b H CH(CH3)CH2CH3 4-CF3-phenyl 0.64 1.62 >156 >781
5c H CH(CH3)CH2CH3 benzyl 0.81 1.88 >123 >617
5d CH3 CH(CH3)CH2CH3 4-F-phenyl 2.2 3.43 >46
>227
5e H CH(CH3)2 4-CF3-phenyl 2.3 3.92 >43

Note: aIC50 (µM): compound concentration that reduced the parasite load by 50%. bSI: selectivity index (CC50/IC50). P. falciparum 3D7 sensitive and RKL-9 CQ resistant strains.