Table 7.

Inhibition of several L. species proliferation for benzimidazoles 7a,b and miltefosine.

Compound 7a, R = OH, R1 = Br 7b, R = OCH3, R1 = H	7a	7b	Miltefosine	7a	7b	Miltefosine
Promastigotes IC50a				SIb
L. mexicana	2.62	3.21	15.34	91.76	317.75	10.23
L. braziliensis	54.05	127.7	48.37	4.88	9.61	3.25
L. donovani	198.47	223.8	114.68	1.33	5.48	1.37
Amastigotes IC50a				SIb
L. mexicana	0.28	0.26	0.51	942.8	3939.2	307.8
L. braziliensis	34.22	33.78	22.67	7.71	30.32	6.92
L. donovani	222.23	218.24	66.74	1.18	4.69	2.35

Note: ^aIC₅₀ (µM): compound concentration that reduced the parasite load of 50%; ^bSI: selectivity index (CC₅₀/IC₅₀); CC₅₀ from J774.2 cells.