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. 2024 Apr 22;15:1382320. doi: 10.3389/fimmu.2024.1382320

Figure 4.

Figure 4

Subpopulation analysis of B cells. (A) Uniform Manifold Approximation and Projection (UMAP) showing two B-cell subpopulation clusters in all samples (HCs, AChR-positive MG, and seronegative MG pre-/post-IVIg treated patients). (B) Box plots showing the cell frequencies of each B-cell subpopulation cluster in each group. Numerical values show the median for each group. Red lines and asterisks show statistically significant combinations based on Tukey’s HSD test (*P < 0.05 and **P < 0.005). (C) Violin plots showing the gene expression levels of B-cell marker genes for each B-cell subpopulation cluster. (D) Scatter plots between the frequency of each B-cell subpopulation cluster and disease severity score with Pearson’s correlation coefficient. Numerical values show the correlation coefficient using 30 MG patient samples (AChR-positive MG and seronegative MG pre-/post-IVIg treated patients). The blue line indicates the regression line, and the gray zone indicates the 95% confidence interval. MG, myasthenia gravis; AChR+, acetylcholine receptor-positive; SN, seronegative; IVIg, intravenous immunoglobulin.