Fig. 1.

TREM2 expression is increased in atherosclerotic plaques. a The mRNA levels of TREM2 in human atherosclerotic plaque and non-carotid plaque vascular tissue (adjacent carotid tissue). The original data came from the GEO database GSE43292. student’s t test. b TREM2 mRNA was detected in the aorta from ApoE^−/− mice fed a HFD for different periods (week; n = 5/group, one-way ANOVA test followed by a post hoc Tukey’s test). c Graph shows the trend of TREM2 mRNA expression after stimulation with oxLDL (50 µg/mL) for different times (n = 4/group, one-way ANOVA followed by a post hoc Tukey’s test). d, e Representative confocal images of TREM2 (red) in the atherosclerotic plaques of the aortic sinus from ApoE^−/− mice in the indicated groups (n = 6/group). Nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI; blue). Scale bar: 50 µm (upper panel), 25 µm (lower panel). One-way ANOVA test followed by a post hoc Tukey’s test. All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001; ns, P > 0.05. AS atherosclerosis, H&E staining hematoxylin–eosin staining