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General phenotypes associated with mitochondrial fission or fusion in cancer stem cells (CSCs). Oncogenic signaling pathways affect mitochondrial dynamics and vice versa; for example, MAPK signaling increases mitochondrial fission whereas Myc has mixed effects. Mitochondrial fission is generally associated with increased rates of mitophagy, EMT, and glycolysis. Conversely, mitochondrial fusion is frequently associated with increased oxidative phosphorylation and therapeutic resistance
