Fig. 1.

LINC01615 is upregulated in response to serum deprivation and predicts poor survival in CRC. A Hierarchical clustering showing differentially expressed lncRNAs of DLD1 cells cultured in normal medium or serum-free medium (FC ≥ 2 or ≤ − 2, p < 0.05). B Hierarchical clustering showing differentially expressed lncRNAs of HCT116 cells cultured in normal medium or serum-free medium (FC ≥ 2 or ≤ − 2, p < 0.05). C Venn diagram showing the numbers of overlapping lncRNAs between the differentially upregulated lncRNAs in HCT116 and DLD1 cells after serum-free medium treatment. D The relative expression of LINC01615 in tumor tissue and corresponding peritumor tissue based on data obtained from the GEO database (GSE70880). E The relative expression levels of LINC01615 were assessed by qRT–PCR in 78 paired CRC tissues and peritumor tissues. F FISH analysis of LINC01615 expression in CRC tissues and peritumor tissues. G Northern blot analysis of LINC01615 expression in DLD1 cells with or without serum supplementation. H LINC01615 expression in CRC tissues from T1–T2 stage CRC patients and T3–T4 stage CRC patients. I Kaplan–Meier analysis of the OS rate and DFS rate in CRC patients in the TCGA database with high or low expression of LINC01615. Data are the means ± SDs (n = 3 independent experiments), **p < 0.01