Fig. 2.

A pathway of protein proteasomal degradation through UPS and counteraction by DUBs. UPS requires a series of processes with involvement of E1, E2, and E3 enzymes. The result of ubiquitination is degradation of the target protein. (blue = E1 enzyme, green = E2 enzyme, purple = E3 enzyme, gray = target protein, red = DUB)