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. 2022 Jul 11;79(8):415. doi: 10.1007/s00018-022-04432-w

Table 2.

Expression of ABC transporters at the developing BBB of human, guinea pig, mouse and rat

ABC transporter Earliest expression at BBB during development
Human Guinea pig Mouse Rat
ABCB1 (P-gp)

GW 7–8

[119, 120]

GD 40*

[126]

GD10.5

[127]

GD13*

[122]
ABCG2 (BCRP)

GW 5 GW

[119]

GD 40*

[126]

GD12.5*

[128]

GD13*

[122]
ABCC1 (MRP-1)

GW 5 GW

[119]

 N/A N/A

GD13*

[122]
ABCC4 (MRP4) N/A N/A N/A

GD13*

[122]

GW gestation week, GD gestation day, N/A not available

*Earliest studied