Table 3.

Ku70 and Ku80 knockout phenotypes in mice

Ku70 Knockout Mice	Ku80 Knockout Mice
Viable	Viable
Can reproduce	Can reproduce
Ku70 knockout mother unable to sustain pups	Ku80 knockout mother unable to sustain pups
K/O mice smaller than control mice	K/O mice smaller than control mice
Fewer proliferating cells	Early loss of proliferating cells for fibroblasts
Premature senescence of cells	Fibroblasts show prolonged doubling time
Cells sensitive to ionizing radiation	Cells are radiation sensitive
Lack mature B cells or serum immunoglobulin	Arrest in T and B lymphocyte development
V(D)J rearrangement deficiency	V(D)J rearrangement deficiency
Increased incidence of thymic tumors	Smaller spleen and lymph nodes
Chromosomal instability	Chromosomal instability
	Early aging/shorter lifespan