Figure 6.
hPSC-derived HLF+ HOXA+ hematopoietic progenitors express similar levels of hallmark HSC markers as human fetal dorsal aorta HSCs
(A) scRNA-seq of day-10 hPSC-derived hematopoietic progenitors, showing gene expression (left) and clustering-based cell-type assignment (right). Entire population is shown, without preselecting cells.
(B) Bulk-population RNA-seq comparison of day-10 hPSC-derived hematopoietic progenitors vs. CD45+ CD144+ HSCs vs. CD45+ CD144− non-HSCs from Carnegie stage 15/16 human embryo aorta-gonad-mesenephros (AGM) region.143 TPM, transcripts per million.
(C and D) scRNA-seq of day-10 hPSC-derived hematopoietic progenitors, compared with (C) HSCs and (D) all cells originating from CS15 human embryo AGM.30
Histograms depict the mean ± SEM.
Related to Figure S7.