Fig. 1.

Dose dependency of the 10 TAS2R14 antagonists identified in this study and their 2D structure. Values represent the means, error bars indicate SEM of 2–11 independent experiments, each treatment performed in three replicates. a Derivatives of FFA showing antagonistic effect on TAS2R14 in the presence of 1 µM of FFA. b Antagonists identified through the computational methodology having a different scaffold compared to the FFA derivatives. c Dose dependency of the inhibitory effect of 4 TAS2R14 antagonists identified in this study in the presence of 1 µM aristolochic acid