Table 1.

Comparison of MB-assisted drug delivery systems

Parameter	MB and free drug (Physical mixtures)	Cargo-loaded MBs
Application	Tumor therapy [123–126]	Tumor therapy [134, 135]
	Immune therapy [117–122]	Immune therapy [136]
	Thrombolysis [127]	Neointimal hyperplasia inhibition [132, 133]
	Antibacterial infection [128–131]	Hair growth recovery [87]
		Antibacterial infection [85, 137]
		Vaccine therapy [138–140]
Preparation	Easy [123–126]	Dependent on cargo property [76, 78, 81, 83–91]
Activation step	Injected as ready to use [128, 129]	Injected as ready to use [87, 134, 135]
	Drug administration following MBs injection [113–116]
Activation time	Few seconds to few minutes [104–107]	Immediately [95–97]
Advantages	Easy preparation [123–126]	Reduced systemic cytotoxicity of drug [78]
		Prolonged drug lifetime within circulation [141–143]
Disadvantages	Direct drug exposure in blood circulation [245]	Poor stability, payload highly dependent on cargo property, risk of drug leakage [246]