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The Notch signalling pathway. When a ligand on the surface of the signal-sending cell interacts with the Notch receptor present at the membrane of the neighbouring signal-receiving cell, two cleavage events are activated: First, ADAM10 releases the NECD. Next, γ-secretase frees the NICD from the transmembrane domain. The NICD then translocates to the nucleus where it forms an activation complex and drives the transcription of downstream targets
