Fig. 3.

Complex crosstalk between Notch and Hh signalling pathways. The complex web of regulation between the Notch and Hh signalling pathways is shown. Hh control of Notch output is shown in purple: (1) Downstream effectors of the Hh pathway control transcription of Notch ligands and regulators, such as Fringe proteins. (2) The Gli proteins provide direct, Notch-independent transcriptional control of some Notch target genes. Notch signalling control of Hh output is shown in orange: (1) Downstream effectors of Notch signalling control the trafficking of Hh pathway components, such as Ptc and Smo, to the primary cilia. (2) NICD directly controls transcription of the Gli genes. (3) Downstream effectors of Notch signalling control Gli protein levels, independent of transcription. Both Notch and Hh signalling pathways are subject to Numb-regulated suppression (shown in light blue)